Novel benzimidazolium salts and their silver(I)-<i>N</i>-heterocyclic carbene complexes: synthesis, characterization and their biological properties

This study was conducted to synthesize and characterize 1,3-dialkyl-5,6-dimethyl-benzimidazolium salts their silver complexes. Four novel silver(I)-N-heterocyclic carbene complexes were synthesized characterized by mass analyses, FT-IR NMR spectroscopy. The biological capacity of the compounds evaluated in vitro for antimicrobial antitumor activities. minimum inhibitory concentration (MIC) determined E. coli, P. aeruginosa, S. aureus, C. glabrata albicans through BMD (Broth Microdilution). results indicated that silver(I)-NHC exhibit activity. In particular, complex 3c presented a significant broad-spectrum anticancer properties against MCF-7, HCT116, SH-SY5Y BEAS-2B cell lines. Anticancer activity measurements carried out according Alamar Blue assay. Efficacy established comparison with cisplatin.